Artificial intelligence in pharmacy refers to the application of artificial intelligence (AI) techniques across pharmaceutical research and practice, including drug discovery, drug delivery, safety monitoring, clinical decision support, and pharmacy operations. Machine learning, deep learning, and natural language processing have been applied to tasks ranging from molecular design to patient adherence monitoring, with the aim of reducing development costs, improving accuracy, and personalizing treatment. Adoption has been uneven. Barriers include limited AI training among pharmacists, high infrastructure costs, and the risk of harm from models trained on unrepresentative data. Regulatory frameworks for AI-based pharmaceutical tools remain in active development across most jurisdictions. == Applications == === Drug discovery and development === Drug development is resource-intensive: bringing a single drug to market typically costs around $2.6 billion and takes 12–14 years. Machine learning algorithms have been applied to analyze molecular datasets to identify potential drug candidates, predict drug–target interactions, and optimize formulations. Artificial neural networks and generative adversarial networks have been used in drug discovery tasks including virtual screening, structure-activity relationship modeling, and de novo molecule generation. Peptides designed using AI methods have shown activity against multidrug-resistant bacteria, and transcriptomic data from human cell lines has been used to train deep learning models to classify drugs by therapeutic properties. Results in drug discovery have been mixed. AI models depend on the quality and diversity of their training data; those trained on narrow chemical libraries can fail to generalize to novel molecular scaffolds. The gap between high virtual screening hit rates and success in preclinical or clinical testing remains a persistent challenge, and the translation of computationally predicted candidates into approved drugs has been slower than early projections suggested. === Drug delivery systems === AI methods including neural networks, principal component analysis, and neuro-fuzzy logic have been applied to identifying biological targets for pharmaceuticals and analyzing genetic information relevant to drug design. Computational models can predict how a formulation will behave in biological systems, helping narrow the field before laboratory synthesis begins. Systems have been proposed that monitor patient response and adjust doses in real time based on individual physiology, with potential applications in chronic disease management. Research has also explored AI applications in targeted cancer treatments and oral vaccine delivery, areas where precise control over drug release kinetics is a design priority. === Drug safety === AI has been applied to predicting and detecting adverse drug reactions using techniques including knowledge graphs, logistic regression classifiers, and neural networks. A 2023 study developed a machine learning algorithm using knowledge graph analysis to classify known causes of adverse reactions. Natural language processing and deep learning models including long short-term memory (LSTM) networks have shown better performance than conventional methods for detecting opioid misuse, drawing on both structured data from electronic health records and unstructured sources such as clinical notes. AI-based pharmacovigilance systems can scan large volumes of electronic health records and social media for drug safety signals at a scale not feasible with manual review. Limitations include difficulty distinguishing drug-related adverse events from unrelated conditions in free-text data, and the need for validated benchmarks to measure model performance against existing safety monitoring standards. === Clinical decision support and personalized medicine === Machine learning systems trained on patient datasets can predict individual risk profiles, including potential allergies and drug–drug interactions, reducing the risk of harm in complex polypharmacy cases where the number of possible interactions exceeds what a clinician can readily assess. Personalized dosing models have been developed for drugs with narrow therapeutic windows — including anticoagulants and immunosuppressants — using patient-specific variables such as weight, renal function, and relevant genetic markers. Prospective clinical validation of these systems has lagged behind their technical development. Most published evaluations report performance on retrospective datasets, and the regulatory pathway for AI-based clinical decision support tools in pharmacy varies by jurisdiction. === Pharmacy operations and automation === Robotic and AI-driven systems have been applied to dispensing accuracy and pharmacy logistics. At the UCSF Medical Center, robotic technology produced 350,000 medication doses with no dispensing errors recorded. Robots such as TUG assist with preparing and transporting medications and laboratory samples within hospital settings. AI has also been applied to inventory management, with demand-forecasting systems predicting medicine requirements to reduce shortages and minimize waste from expired stock. In community pharmacy settings, AI tools have been used to flag potential prescription errors and alert pharmacists to drug–drug interactions before dispensing. === Medication adherence === Confirming that patients take prescribed medications as directed is a persistent challenge in healthcare. AI-enabled tools including smart pillboxes, RFID tags, ingestible sensors, and video check-ins have been applied to this problem. Smart pillboxes record when they are opened, providing real-time adherence data that can be reviewed remotely by care teams. Ingestible sensors transmit a signal after dissolution, offering direct confirmation of ingestion rather than proxy measures such as pill count or self-report. == Adoption challenges == === Barriers === Several barriers limit AI adoption in pharmacy practice. Many published evaluations report model performance on retrospective datasets rather than prospective clinical outcomes, making it difficult to assess real-world benefit. Pharmacists have reported limited AI training and knowledge, and research facilities often lack the computational infrastructure required for model development and validation. Models trained on biased or unrepresentative datasets can produce misleading results with direct patient safety consequences. === Regulatory frameworks === Regulatory frameworks for AI-based pharmaceutical tools are in active development. In the United States, the Food and Drug Administration (FDA) has issued guidance on AI and machine learning-based software as a medical device, addressing requirements for pre-market review and post-market performance monitoring. The European Medicines Agency has published discussion papers on the use of AI across the medicines development lifecycle, with particular attention to transparency in model training and validation. The absence of harmonized international standards creates compliance complexity for developers operating across multiple jurisdictions. === Ethical challenges === AI adoption raises data privacy and security concerns, including the risk of exposing sensitive patient information through data breaches. Algorithmic bias presents a related hazard: a model trained on an unrepresentative patient population may generate unsuitable treatment recommendations for patients not reflected in its training data, with potential for disparate outcomes across demographic groups. The opacity of some machine learning models, particularly deep neural networks, limits clinicians' ability to interpret or contest a recommendation, raising questions of accountability when a model-assisted decision results in patient harm. === Proposed solutions === Responses proposed in the literature include AI-focused education programs for pharmacists, increased public funding for healthcare AI research, encryption and governance frameworks for patient data, and regulatory requirements to prevent the use of biased training datasets. Greater transparency about training data provenance, model architecture, and validation methodology has also been recommended, including disclosure requirements in regulatory submissions. === Future directions === Research groups have called for tighter integration between AI systems and electronic health records to reduce healthcare costs and improve continuity of care across settings. International collaboration through shared AI frameworks and federated learning approaches has been proposed to address data scarcity in underrepresented patient populations and accelerate validation across institutions.
Virtual intelligence
Virtual intelligence (VI) is the term given to artificial intelligence that exists within a virtual world. Many virtual worlds have options for persistent avatars that provide information, training, role-playing, and social interactions. The immersion in virtual worlds provides a platform for VI beyond the traditional paradigm of past user interfaces (UIs). What Alan Turing established as a benchmark for telling the difference between human and computerized intelligence was devoid of visual influences. With today's VI bots, virtual intelligence has evolved past the constraints of past testing into a new level of the machine's ability to demonstrate intelligence. The immersive features of these environments provide nonverbal elements that affect the realism provided by virtually intelligent agents. Virtual intelligence is the intersection of these two technologies: Virtual environments: Immersive 3D spaces provide for collaboration, simulations, and role-playing interactions for training. Many of these virtual environments are currently being used for government and academic projects, including Second Life, VastPark, Olive, OpenSim, Outerra, Oracle's Open Wonderland, Duke University's Open Cobalt, and many others. Some of the commercial virtual worlds are also taking this technology into new directions, including the high-definition virtual world Blue Mars. Artificial intelligence (AI): AI is a branch of computer science that aims to create intelligent machines capable of performing tasks that typically require human intelligence. VI is a type of AI that operates within virtual environments to simulate human-like interactions and responses. == Applications == Cutlass Bomb Disposal Robot: Northrop Grumman developed a virtual training opportunity because of the prohibitive real-world cost and dangers associated with bomb disposal. By replicating a complicated system without having to learn advanced code, the virtual robot has no risk of damage, trainee safety hazards, or accessibility constraints. MyCyberTwin: NASA is among the companies that have used the MyCyberTwin AI technologies. They used it for the Phoenix rover in the virtual world Second Life. Their MyCyberTwin used a programmed profile to relay information about what the Phoenix rover was doing and its purpose. Second China: The University of Florida developed the "Second China" project as an immersive training experience for learning how to interact with the culture and language in a foreign country. Students are immersed in an environment that provides role-playing challenges coupled with language and cultural sensitivities magnified during country-level diplomatic missions or during times of potential conflict or regional destabilization. The virtual training provides participants with opportunities to access information, take part in guided learning scenarios, communicate, collaborate, and role-play. While China was the country for the prototype, this model can be modified for use with any culture to help better understand social and cultural interactions and see how other people think and what their actions imply. Duke School of Nursing Training Simulation: Extreme Reality developed virtual training to test critical thinking with a nurse performing trained procedures to identify critical data to make decisions and performing the correct steps for intervention. Bots are programmed to respond to the nurse's actions as the patient with their conditions improving if the nurse performs the correct actions.
Hard sigmoid
In artificial intelligence, especially computer vision and artificial neural networks, a hard sigmoid is non-smooth function used in place of a sigmoid function. These retain the basic shape of a sigmoid, rising from 0 to 1, but using simpler functions, especially piecewise linear functions or piecewise constant functions. These are preferred where speed of computation is more important than precision. == Examples == The most extreme examples are the sign function or Heaviside step function, which go from −1 to 1 or 0 to 1 (which to use depends on normalization) at 0. Other examples include the Theano library, which provides two approximations: ultra_fast_sigmoid, which is a multi-part piecewise approximation and hard_sigmoid, which is a 3-part piecewise linear approximation (output 0, line with slope 0.2, output 1).
Mark V. Shaney
Mark V. Shaney is a synthetic Usenet user whose postings in the net.singles newsgroups were generated by Markov chain techniques, based on text from other postings. The username is a play on the words "Markov chain". Many readers were fooled into thinking that the quirky, sometimes uncannily topical posts were written by a real person. The system was designed by Rob Pike with coding by Bruce Ellis. Don P. Mitchell wrote the Markov chain code, initially demonstrating it to Pike and Ellis using the Tao Te Ching as a basis. They chose to apply it to the net.singles netnews group. The program is fairly simple. It ingests the sample text (the Tao Te Ching, or the posts of a Usenet group) and creates a massive list of every sequence of three successive words (triplet) which occurs in the text. It then chooses two words at random, and looks for a word which follows those two in one of the triplets in its massive list. If there is more than one, it picks at random (identical triplets count separately, so a sequence which occurs twice is twice as likely to be picked as one which only occurs once). It then adds that word to the generated text. Then, in the same way, it picks a triplet that starts with the second and third words in the generated text, and that gives a fourth word. It adds the fourth word, then repeats with the third and fourth words, and so on. This algorithm is called a third-order Markov chain (because it uses sequences of three words). == Examples == A classic example, from 1984, originally sent as a mail message, later posted to net.singles is reproduced here: >From mvs Fri Nov 16 17:11 EST 1984 remote from alice It looks like Reagan is going to say? Ummm... Oh yes, I was looking for. I'm so glad I remembered it. Yeah, what I have wondered if I had committed a crime. Don't eat with your assessment of Reagon and Mondale. Up your nose with a guy from a firm that specifically researches the teen-age market. As a friend of mine would say, "It really doesn't matter"... It looks like Reagan is holding back the arms of the American eating public have changed dramatically, and it got pretty boring after about 300 games. People, having a much larger number of varieties, and are very different from what one can find in Chinatowns across the country (things like pork buns, steamed dumplings, etc.) They can be cheap, being sold for around 30 to 75 cents apiece (depending on size), are generally not greasy, can be adequately explained by stupidity. Singles have felt insecure since we came down from the Conservative world at large. But Chuqui is the way it happened and the prices are VERY reasonable. Can anyone think of myself as a third sex. Yes, I am expected to have. People often get used to me knowing these things and then a cover is placed over all of them. Along the side of the $$ are spent by (or at least for ) the girls. You can't settle the issue. It seems I've forgotten what it is, but I don't. I know about violence against women, and I really doubt they will ever join together into a large number of jokes. It showed Adam, just after being created. He has a modem and an autodial routine. He calls my number 1440 times a day. So I will conclude by saying that I can well understand that she might soon have the time, it makes sense, again, to get the gist of my argument, I was in that (though it's a Republican administration). _-_-_-_-Mark Other quotations from Mark's Usenet posts are: "I spent an interesting evening recently with a grain of salt." (Alternatively reported as "While at a conference a few weeks back, I spent an interesting evening with a grain of salt.") "I hope that there are sour apples in every bushel." (see also sour grapes) == History == In The Usenet Handbook Mark Harrison writes that after September 1981, students joined Usenet en masse, "creating the USENET we know today: endless dumb questions, endless idiots posing as savants, and (of course) endless victims for practical jokes." In December, Rob Pike created the netnews group net.suicide as prank, "a forum for bad jokes". Some users thought it was a legitimate forum, some discussed "riding motorcycles without helmets". At first, most posters were "real people", but soon "characters" began posting. Pike created a "vicious" character named Bimmler. At its peak, net.suicide had ten frequent posters; nine were "known to be characters." But ultimately, Pike deleted the newsgroup because it was too much work to maintain; Bimmler messages were created "by hand". The "obvious alternative" was software, running on a Bell Labs computer created by Bruce Ellis, based on the Markov code by Don Mitchell, which became the online character Mark V. Shaney. Kernighan and Pike listed Mark V. Shaney in the acknowledgements in The Practice of Programming, noting its roots in Mitchell's markov, which, adapted as shaney, was used for "humorous deconstructionist activities" in the 1980s. Dewdney pointed out "perhaps Mark V. Shaney's magnum opus: a 20-page commentary on the deconstructionist philosophy of Jean Baudrillard" directed by Pike, with assistance from Henry S. Baird and Catherine Richards, to be distributed by email. The piece was based on Jean Baudrillard's "The Precession of Simulacra", published in Simulacra and Simulation (1981). == Reception == The program was discussed by A. K. Dewdney in the Scientific American "Computer Recreations" column in 1989, by Penn Jillette in his PC Computing column in 1991, and in several books, including the Usenet Handbook, Bots: the Origin of New Species, Hippo Eats Dwarf: A Field Guide to Hoaxes and Other B.S., and non-computer-related journals such as Texas Studies in Literature and Language. Dewdney wrote about the program's output, "The overall impression is not unlike what remains in the brain of an inattentive student after a late-night study session. Indeed, after reading the output of Mark V. Shaney, I find ordinary writing almost equally strange and incomprehensible!" He noted the reactions of newsgroup users, who have "shuddered at Mark V. Shaney's reflections, some with rage and others with laughter:" The opinions of the new net.singles correspondent drew mixed reviews. Serious users of the bulletin board's services sensed satire. Outraged, they urged that someone "pull the plug" on Mark V. Shaney's monstrous rantings. Others inquired almost admiringly whether the program was a secret artificial intelligence project that was being tested in a human conversational environment. A few may even have thought that Mark V. Shaney was a real person, a tortured schizophrenic desperately seeking a like-minded companion. Concluding, Dewdney wrote, "If the purpose of computer prose is to fool people into thinking that it was written by a sane person, Mark V. Shaney probably falls short." A 2012 article in Observer compared Mark V. Shaney's "strangely beautiful" postings to the Horse_ebooks account on Twitter and music reviews at Pitchfork, saying that "this mash-up of gibberish and human sentiment" is what "made Mark V. Shaney so endlessly fascinating".
CLEVER score
The CLEVER (Cross Lipschitz Extreme Value for nEtwork Robustness) score is a way of measuring the robustness of an artificial neural network towards adversarial attacks. It was developed by a team at the MIT-IBM Watson AI Lab in IBM Research and first presented at the 2018 International Conference on Learning Representations. It was mentioned and reviewed by Ian Goodfellow as well. It was adopted into an educational game Fool The Bank by Narendra Nath Joshi, Abhishek Bhandwaldar and Casey Dugan
List of artificial intelligence journals
This is a list of notable peer-reviewed academic journals that publish research in the field of artificial intelligence (AI), including areas such as machine learning, computer vision, natural language processing, robotics, and intelligent systems. == General artificial intelligence == Artificial Intelligence (journal) – Elsevier Journal of Artificial Intelligence Research (JAIR) – AI Access Foundation Knowledge-Based Systems – Elsevier == Machine learning == Data Mining and Knowledge Discovery – Springer Machine Learning (journal) – Springer Journal of Machine Learning Research – Microtome Pattern Recognition (journal) – Elsevier Neural Networks (journal) – Elsevier Neural Computation (journal) – MIT Press Neurocomputing (journal) - Elsevier == Deep learning and neural computation == IEEE Transactions on Evolutionary Computation – IEEE IEEE Transactions on Neural Networks and Learning Systems – IEEE Nature Machine Intelligence – Springer Nature == Computer vision == International Journal of Computer Vision – Springer IEEE Transactions on Pattern Analysis and Machine Intelligence – IEEE Machine Vision and Applications – Springer == Natural language processing == Computational Linguistics (journal) – MIT Press Natural Language Processing Transactions of the Association for Computational Linguistics – ACL == Robotics and intelligent systems == IEEE Transactions on Robotics – IEEE Autonomous Robots – Springer Journal of Intelligent & Robotic Systems – Springer == Interdisciplinary and ethics in AI == AI & Society – Springer Artificial Life – MIT Press Philosophy & Technology – Springer Minds and Machines – Springer
Amália (LLM)
Amália is a Portuguese large language model (LLM) announced in November 2024 by the Portuguese Prime-Minister Luís Montenegro. Its final version is expected to be launched in 2026. It is being developed by Center for Responsible AI (Centro para a AI Responsável) and by the research centers of NOVA School of Science and Technology and Instituto Superior Técnico. == History == In 2024 it was announced that the Portuguese Agency for Administrative Modernization (Agência para a Modernização Administrativa) transpose this LLM to Portuguese Public Administration. According to Paulo Dimas (CEO of the Center for Responsible AI) the three fundamental points of this LLM project are the linguistic variant (European Portuguese), cultural representation and data protection. In April 2025 it was announced that Amália had entered beta phase with an improved version being expected to be launched in September 2025. The beta version released in September is available only to the Public Administration, but the website launched in October reiterates the final version will be an open model.